发明名称 COMBINED THERAPY OF DITERPENOID TRIEPOXIDES AND TRAIL FOR SYNERGISTIC KILLING OF TUMOR CELLS
摘要 <p>A synergistic combination of TRAIL or ligands that interact with TRAIL receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the invention include TRAIL, analogs thereof, stabilized multimers of TRAIL, TRAIL mimetics, etc. Of particular interest are combined therapy with the diterpenoid triepoxides triptolide and derivatives and analogs thereof.</p>
申请公布号 WO2000048619(A1) 申请公布日期 2000.08.24
申请号 US2000003891 申请日期 2000.02.15
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