New N-substituted hexahydro-2,6-methano-3-benzazocin-10-ol derivatives, as tension-dependent sodium channel blockers useful for treating e.g. arrhythmia, spasms, pain or neurodegenerative diseases

摘要

N-(5-Phenyl-tetrahydrofuran-2-ylmethyl or 6-phenyl-tetrahydropyran-2-ylmethyl)-1,2,3,4,5,6-tetrahydro-2,6-methan o-3-benzazocin-10-ol derivatives (I) are new. N-(5-Phenyl-tetrahydrofuran-2-ylmethyl or 6-phenyl-tetrahydropyran-2-ylmethyl)-1,2,3,4,5,6-tetrahydro-2,6-methan o-3-benzazocin-10-ol derivatives of formula (I), their free bases and acid addition salts are new. R1, R2 = H, Me or F; n = 1 or 2; R3 = H, halo, OH, Me, Et or OMe; R4, R5 = H or Me; R6 = H, Me or Et. An Independent claim is included for the preparation of (I).