发明名称 |
NG2/HM PROTEOGLYCAN-BINDING PEPTIDES THAT HOME TO ANGIOGENIC VASCULATURE AND RELATED METHODS |
摘要 |
The present invention provides angiogenic vasculature homing molecules that bind to NG2/HM proteoglycan, including, for example, a peptide comprising the amino acid sequence TAASGVRSMH (SEQ ID NO:1) or LTLRWVGLMS (SEQ ID NO:2). The invention also provides conjugates comprising an angiogenic vasculature homing molecule linked to a moiety such as a drug, a cytotoxic agent, a chemotherapeutic agent, or a detectable agent. The invention additionally provides a method of targeting angiogenic vasculature in a tumor in vivo by contacting the angiogenic vasculature with an angiogenic vasculature homing molecule that selectively homes to a NG2/HM proteoglycan, wherein the angiogenic vasculature homing molecule is not an antibody. The invention additionally provides a method of inhibiting angiogenesis in a tumor of a subject by administering to the subject a conjugate comprising a moiety linked to an angiogenic vasculature homing molecule that selectively binds a NG2/HM proteoglycan, wherein the angiogenic vasculature homing molecule is not an antibody.
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申请公布号 |
WO0048464(A1) |
申请公布日期 |
2000.08.24 |
申请号 |
WO2000US03864 |
申请日期 |
2000.02.16 |
申请人 |
THE BURNHAM INSTITUTE |
发明人 |
BURG, MICHAEL, A.;PASQUALINI, RENATA;ARAP, WADIH;RUOSLAHTI, ERKKI, I.;STALLCUP, WILLIAM, B. |
分类号 |
A61K38/00;C07K7/06;(IPC1-7):A01N63/00;C12N15/00;A01N43/04 |
主分类号 |
A61K38/00 |
代理机构 |
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