| 摘要 |
PCT No. PCT/JP98/03375 Sec. 371 Date May 14, 1999 Sec. 102(e) Date May 14, 1999 PCT Filed Jul. 29, 1998 PCT Pub. No. WO99/06364 PCT Pub. Date Feb. 11, 1999The present invention has for its object to provide a commercially useful, expedient and efficient method for purification and isolation of an N-protected (2S,3R)-1-halo-2-hydroxy-3-amino-4-phenylthiobutane (1) or its enantiomer, which is capable of removing the various contaminants, particularly said byproducts, whereby the problem of instability of the compound (1) or its enantiomer can be overcome and a high product yield can be insured. The present invention relates to a method of purifying and isolating an N-protected (2S,3R)-1-halo-2-hydroxy-3-amino-4-phenylthiobutane (1): (wherein X represents a halogen atom; one of P1 and P2 represents a hydrogen atom and the other represents an amino-protecting group, or P1 and P2 taken together represents an amino-protecting group) or its enantiomer, which comprises using an aromatic hydrocarbon solvent to remove impurities occurring in said compound (1) or impurities occurring in said enantiomer from said compound (1) containing impurities or its enantiomer containing impurities and isolate said compound (1) or said enantiomer as crystals.
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