发明名称 |
Method for preventing HIV-1 infection of CD4+ cells |
摘要 |
This invention provides methods for inhibiting fusion of HIV-1 to CD4+ cells which comprise contacting CD4+ cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+ cells is inhibited. This invention also provides methods for inhibiting HIV-1 infection of CD4+ cells which comprise contacting CD4+ cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+ cells is inhibited, thereby inhibiting the HIV-1 infection. This invention provides non-chemokine agents capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4+ cells. This invention also provides pharmaceutical compositions comprising an amount of the non-chemokine agent capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4+ cells effective to prevent fusion of HIV-1 to CD4+ cells and a pharmaceutically acceptable carrier.
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申请公布号 |
US6107019(A) |
申请公布日期 |
2000.08.22 |
申请号 |
US19970876078 |
申请日期 |
1997.06.13 |
申请人 |
PROGENICS PHARMACEUTICALS, INC. |
发明人 |
ALLAWAY, GRAHAM P.;LITWIN, VIRGINIA M.;MADDON, PAUL J.;OLSON, WILLIAM C. |
分类号 |
A61K38/00;C07K14/16;C07K14/52;C07K14/715;C07K14/73;G01N33/566;G01N33/569;G01N33/68;(IPC1-7):C12Q1/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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