Esculentin A and esculentin B, a process for their preparation, and their use in the manufacture of medicaments

摘要

The compounds 18 beta , 19 beta -diacetyloxy-18 alpha , 19 alpha -epoxy-3, 13(16), 14-clerodatrien-2-one (Esculentin A) and 18 beta , 19 beta -diacetyloxy-18 alpha , 19 alpha -epoxy-3, 12, 14-clerodatrien-2 beta -isovaleryloxy-6 beta , 7 alpha -diol (Esculentin B) obtained from plants belonging to the Samydaceae family, particularly Casearia esculenta, a process for their preparation, and their use in the manufacture of medicaments. The compounds are particularly useful as anti-inflammatory and/or anti-cancer agents.