发明名称 |
2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives and a process for the preparation thereof |
摘要 |
The present invention relates to the compound of formulae and to a process for the manufacture of compounds of the general formula which are ligands for the metabotropic glutamate receptors of group II, wherein T is tritium; R1 is hydroxy, lower alkoxy, lower alkenyloxy, benzyloxy, hydrogen, deuterium or tritium; R11 is hydrogen, deuterium or tritium, hydroxy or amino, and R2 is hydrogen or tritium, or R1 and R2 form a bond.
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申请公布号 |
US6107342(A) |
申请公布日期 |
2000.08.22 |
申请号 |
US19990385935 |
申请日期 |
1999.08.30 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
ADAM, GEO;HUGUENIN-VIRCHAUX, PHILIPPE NICOLAS;MUTEL, VINCENT;STADLER, HEINZ;WOLTERING, THOMAS JOHANNES |
分类号 |
A61K31/00;A61K31/196;A61P25/00;A61P25/18;C07C227/16;C07C227/32;C07C229/50;C07C247/14;(IPC1-7):A61K31/195;C07C61/28;C07C247/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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