Inhibitor for narcotic analgesic dependence/resistance acquisition

摘要

PCT No. PCT/JP96/02207 Sec. 371 Date Mar. 19, 1998 Sec. 102(e) Date Mar. 19, 1998 PCT Filed Aug. 6, 1995 PCT Pub. No. WO97/06139 PCT Pub. Date Feb. 20, 1997A medicament which comprises as an active ingredient a compound represented by the following formula: R2-CH2CONH-R1 wherein R1 represents a pyridyl group, a substituted pyridyl group, phenyl group, or a substituted phenyl group; and R2 represents 2-oxo-1-pyrrolidinyl group which may optionally be substituted, and inhibits the development of dependency induced by a narcotic analgesic and/or inhibit the development of tolerance to analgesic action induced by a narcotic analgesic agent.