| 摘要 |
The invention identifies a novel mRNA transcript in man, mouse and the rat which encodes a CTLA-4 molecule which lacks the transmembrane region, and thus represents a native soluble form of CTLA-4. This shortened CTLA-4 transcript and its predicted polypeptide product are designated sCTLA-4. The nucleotide and the predicted amino acid sequences encoding the human, rat and mouse sCTLA-4 molecules are provided.
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