SERUM ALBUMIN-BASED PARENTERAL FORMULATIONS OF POLYENE MACROLIDES

摘要

The present invention provides a method for producing a polyene macrolide-human serum albumin solid dispersion having increased solubility over polyene macrolide alone or polyene macrolide mixed with human serum albumin. It also shows no loss in antifungal activity. The solid dispersion is produced by dissolving the polyene macrolide in a cosolvent; mixing in the human serum albumin solution; and freeze-drying the solution to form a solid dispersion. The solid dispersion is reconstituted prior to administration. Prior to freeze-drying, the composition may be incubated at elevated temperatures.