The invention relates to a product comprised of specific combinations of cell lines intended for use as an allogeneic immunotherapy agent for the treatment of prostate cancer in humans. The heterogeneity of the immunotherapeutic matches the heterogeneity of the antigenic profile in the target prostate cancer and immunises the recipients with many of the potential TAA and TSA which are expressed at various stages of the disease. The invention discloses a vaccine comprising a combination of three different cell lines prepared from primary or metastatic prostate cancer biopsy material. The cell lines are lethally irradiated utilising gamma irradiation at 50-300 Gy to ensure that they are replication incompetent.
申请公布号
WO0033870(A3)
申请公布日期
2000.08.17
申请号
WO1999GB04135
申请日期
1999.12.09
申请人
ONYVAX LIMITED;DALGLEISH, ANGUS, GEORGE;SMITH, PETER, MICHAEL;SUTTON, ANDREW, DEREK;WALKER, ANTHONY, IAN
发明人
DALGLEISH, ANGUS, GEORGE;SMITH, PETER, MICHAEL;SUTTON, ANDREW, DEREK;WALKER, ANTHONY, IAN