The present invention features compositions and methods that are useful for storing labeled detection probes and detecting whether a target nucleic acid sequence is present in a sample. Preferred compositions are made up of a detection probe containing a label susceptible to a chemical or enzymatic alteration and a protection probe that protects the label from alteration and/or decreases the ability of the detection probe to inhibit nucleic acid amplification. Such compositions can be used, for example, to stabilize a detection probe label and to prevent a detection probe from hybridizing prematurely to amplified or target nucleic acid.
申请公布号
WO0047777(A1)
申请公布日期
2000.08.17
申请号
WO2000US03525
申请日期
2000.02.11
申请人
GEN-PROBE INCORPORATED;BRENTANO, STEVEN, T.;MCDONOUGH, SHERROL, H.;NELSON, NORMAN, C.
发明人
BRENTANO, STEVEN, T.;MCDONOUGH, SHERROL, H.;NELSON, NORMAN, C.