摘要 |
<p>The present invention relates to novel tyrosine alkoxyguanidine compounds that are inhibitors of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including conditions such as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have general formula (IV), where R?1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11¿, m and n are defined herein.</p> |