STEREOSELECTIVE SYNTHESIS OF NUCLEOSIDE ANALOGUES

摘要

The present invention provides a process for making stereochemically pure dioxolane nucleoside analogues. The process includes the use of hydrolytic enzymes for separating .beta. and .alpha. anomers from an anomeric mixture represented by formula (A) or formula (B) wherein W is benzyl or benzoyl; R1 is selected from the group consisting of C1-6 alkyl and C6-15 aryl.