Peptide vaccine for canine allergy

摘要

Disclosed is an isolated and purified peptide comprising a leucine positioned two peptide bonds away from a tyrosine-arginine pair, such as having the configuration: leucine-blank-blank-tyrosine-arginine, tyrosine-arginine-blank-blank-leucine, or, leucine-blank-blank-tyrosine-arginine-blank-blank-leucine, where blank is any amino acid. Other peptides of the invention include those with the sequence cysteine-blank-blank-proline-histidine-blank-blank-blank-cysteine; cysteine-blank-proline-histidine-blank-proline-blank-blank-cysteine. The peptides can be linked to a carrier such as a multiply antigen protein or a plant virus particle. Isolated and purified peptides of the invention can be used to induce canine autoantibodies directed to the canine IgE molecule.