POLY(ESTER-ANHYDRIDES) AND INTERMEDIATES THEREFOR

摘要

Biodegradable poly(ester-anhydrides) designed to display two-stage degradation profiles are described. The presence of the anhydride linkages allows a relatively rapid decrease in molecular weight, the extent of which is governed by the concentration of the anhydride linkages along the chain, followed by possible dissolution and a slower degradation of the remaining oligomers, the rate of which is governed by the composition of the polyester prepolymers. Methods for the preparation of the poly(ester-anhydrides) and their polyester precursors are also described./!