Novel protein: prenyl transferase inhibitors

摘要

The invention pertains to novel peptide analogues suitable for inhibiting protein:prenyl transferased. The analogues comply with the following formula: in which: R<1> is hydrogen or a thiol-protecting group; R<2> and R<3> are independently hydrogen or C1-C4 alkyl; R<4> is hydrogen, C1-C4 alkyl, C1-C4 acyl or peptidyl; R<5> is hydrogen or C1-C4 alkyl; R<6> is hydrogen or optionally substituted C1-C6 alkyl; A is a direct bond or an optionally substituted C1-C4 alkylene chain; Y represents an oxo group or two hydrogen atoms; Z is oxygen, sulphur, imino or C1-C8 alkyl-, aryl- or acylimino; m is 0, 1 or 2; n is 0 or 1.el