INTERMEDIATE USEFUL FOR MANUFACTURING CEFIXIME AND PREPARING METHOD THEREOF

摘要

PURPOSE: A method for preparing intermediates for use in preparing cefixime by preparing 3-vinyl cephalosphorin-based derivatives with reactive organic acid is provided which can produce the title compound in a high purity and a high yield in a simple manner. CONSTITUTION: An intermediate represented by the formula 1 having a 2-£aminothiazolyl|-2£tertiary-buthoxy carbonyl|methoxyiminoacetamido side chain at the 7-position of a cephalosphorin nucleus is prepared by acilating 3-vinyl cephalosphorin derivatives represented by the formula 3 and reactive thiophosphate of thiazole acetic acid represented by the formula 2 in the presence of a solvent and a base. In formula, h, para-methoxybenzyl or diphenylmethyl.