| 摘要 |
PURPOSE: A process for preparing aromatic propionic acids using fluorobiphenyl instead of bromine group substituted fluorobiphenyl is provided which can produce the title compounds in a high yield and in a simple manner. CONSTITUTION: 2-Fluorobiphenyl of the formula 2 and halogenated aluminium or halogenated zinc are reacted with 2-bromopropionate of the formula 3, acid-treated, and crystallized with a solvent at -20 to 50°C (preferably 0 to 20°C) to give a compound of the formula 1 having a strong and persistent effect upon analgesia and antiphlogosis. The metal catalyst uses magnesium or zinc in an amount of 0.2 to 5 equivalent. The solvent is an organic solvent such as ethyl acetate, ether, acetone, benzene, toluene, 1,4-dioxane, and tetrahydrofuran. The process is industrially advantageous without requiring separate purification processes because of producing no side products.
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