发明名称 |
Crystallization process of maleate salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline |
摘要 |
<p>A method for crystallizing the maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (Enalapril) from an aqueous liquid with ease in good yield, which comprises mixing an aqueous liquid containing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, maleic acid and a base and having a pH of 4 or more with an acid in an amount of the acid sufficient to convert the base to a neutral salt, to thereby crystallize N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline in the form of a maleic acid salt.</p> |
申请公布号 |
CZ20001004(A3) |
申请公布日期 |
2000.08.16 |
申请号 |
CZ20000001004 |
申请日期 |
1999.07.19 |
申请人 |
KANEKA CORPORATION |
发明人 |
KINOSHITA KOICHI;MOROSHIMA TADASHI;YANAGIDA YOSHIFUMI;FUSE YOSHIHIDE;UEDA YASUYOSHI |
分类号 |
C07K5/06;C07K5/062;(IPC1-7):C07K5/062;C07K1/30;C07B57/00 |
主分类号 |
C07K5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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