| 摘要 |
Compounds and pharmaceutical compositions, including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, have the formula: CORE MOIETY-(R)j In these compounds, j is an integer from one to three; the core moiety is a cyclic core, the cyclic core being non-cyclic or at least one five- to seven-member non-heterocyclic ring or heterocycle; and R is selected from the group consisting of amine, hydrogen, halogen, hydroxyl, substituted or unsubstituted C(1-10) alkyl, C(2-10) alkenyl, cyclic or heterocyclic group or formula I. At least one R having formula I: In formula I, n is an integer from four to twenty; and each R1 or R2 is independently hydrogen, substituted or unsubstituted C(1-20) alkyl, C(1-20) alkoxyl, C(2-20) alkenyl or cyclic or heterocyclic group. The compounds are useful in treating or preventing, for example, sepsis syndrome, hematopoietic or organ toxicity, cancer, viral activity, AIDS and AIDS-related indications, allopecia caused by cytotoxic therapies, and progression of an inflammatory or autoimmune disease.
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