发明名称 Bi-aromatic compounds and pharmaceutical and cosmetic compositions containing same
摘要 PCT No. PCT/FR98/01238 Sec. 371 Date Mar. 23, 1999 Sec. 102(e) Date Mar. 23, 1999 PCT Filed Jun. 12, 1998 PCT Pub. No. WO98/56783 PCT Pub. Date Dec. 17, 1998The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is -CH3, -CH2-O-R6, -OR6 or -COR7; R2 is -OR8, -SR8 or a polyether radical if in the latter case R4 is C1-C20 alkyl and is in ortho or meta position relative to X-Ar; R3 is alkyl or R2 and R3 together form a cycle optionally interrupted by O or S; R4 is aryl radical; R5 is H, halogen, C1-C20 alkyl or -OR8; R6 is H, alkyl or -COR9; R7 is H, alkyl, -N(r')(r'') or -OR10; R8 is H, alkyl or -COR9; R9 is alkyl; R10 is H, C1-C20 alkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r' and r'' are H, alkyl mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which R11 is H or -OR6; R12 is H or alkyl; or R11 and R12 form an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).
申请公布号 US6103762(A) 申请公布日期 2000.08.15
申请号 US19990242130 申请日期 1999.03.23
申请人 GALDERMA RESEARCH & DEVELOPMENT 发明人 BERNARDON, JEAN-MICHEL;TROUILLE, SIMON
分类号 A61K8/00;A61K8/14;A61K8/30;A61K8/31;A61K8/33;A61K8/35;A61K8/36;A61K8/368;A61K8/37;A61K8/39;A61K8/44;A61K8/46;A61K8/49;A61K8/60;A61K8/64;A61K31/192;A61K31/22;A61K31/35;A61K31/352;A61K31/382;A61P9/00;A61P9/10;A61P11/00;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P17/14;A61P17/16;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P37/08;A61Q5/00;A61Q5/02;A61Q19/00;A61Q19/02;A61Q19/10;C07C65/19;C07C65/28;C07C69/76;C07D213/79;C07D311/58;C07D335/06;C07D405/06;C07D409/06;(IPC1-7):A61K31/015;A61K31/19;A61K31/215;A61K7/02 主分类号 A61K8/00
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