| 摘要 |
Novel medicaments for topical administration are provided herein. Such medicaments comprise a pharmaceutically-active substance or a mixture of pharmaceutically-active: substances which is, or are, suitable for topical administration, with the proviso that the active substance is not an ophthalmic drug, together with hyaluronic acid or a pharmaceutically-acceptable salt of the hyaluronic acid as the drug delivery system, and from 0% up to a topically-suitable amount of an additional excipient. Still further, optionally, these medicaments may also contain an additional pharmaceutically-acceptable excipient. The hyaluronic acid, which typically excludes fractions of molecular weight less than 30,000 Daltons, may be in the form of the free acid or it may be in the form of a salt with an alkali metal, with an alkaline earth metal, with magnesium, with aluminum, with ammonia or with an amine, or may be in the form of a salt with one or more of those pharmaceutically-active substances. Still further, those medicaments may be pharmaceutical compositions for topical administration and comprise, as an active ingredient, a pharmacologically-effective amount of partial salt, or a stoichiometrically-neutral salt, of hyaluronic acid, or a molecular weight fraction thereof, with at least one pharmacologically-active substance of a basic nature which is suitable for topical administration and which is capable of being absorbed intradermally or through the nasal or rectal mucosa, together with an excipient which is suitable for topical administration.
|
