摘要 |
Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.8 m2, in vitro clearances for urea and phosphorus respectively of >/=195, and >/=180, ml/min, a beta 2-microglobulin clearance >/=44 ml/min and an albumin permeability </=0.5%; (2) an albumin permeability </=1.5% and an overall mass transfer coefficient Ko >/=0.0012 cm/min; and (3) a vitamin B12 dialyzance of >/=135 ml/min and an albumin permeability </=3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C. of 25-130 poise and a quantity y % of water given by:-0.01x+1.45</=y</=-0.01x+2.25The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.
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