Thermostable variants of neutral proteases of Bacillus stearothermophilus and Bacillus thermoproteolyticus

摘要

PCT No. PCT/NL95/00037 Sec. 371 Date Sep. 19, 1996 Sec. 102(e) Date Sep. 19, 1996 PCT Filed Jan. 26, 1995 PCT Pub. No. WO95/20663 PCT Pub. Date Aug. 3, 1995The present invention provides genes encoding extremely thermostable variants of neutral proteases, as well as, vectors and cells comprising these genes and proteases produced through these genes, vectors and/or cells. In particular variants of the neutral proteases of Bacillus stearothermophilus and Bacillus thermoproteolyticus (thermolysine) and sequences and cells coding therefor are provided.