CONTROLLED RELEASE BY EXTRUSION OF SOLID AMORPHOUS DISPERSIONS OF DRUGS

摘要

Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.