| 摘要 |
<p>A method of manufacture for the production of transdermal drug delivery matrices and devices, transdermal sampling devices, and dermal conditioning devices. A polymer and an active agent are mixed and heated in a multiple-lobed compounder to produce a polymer mixture. The polymer mixture is extruded and then at least a portion of the extrudate is formed into, for example, the transdermal drug delivery matrix, or incorporated into the transdermal drug delivery device. These alternative methods for preparing transdermal matrices have several advantages over the current methods of manufacture. The matrix components, particularly the active agent, are not exposed to extremes in solvent or temperature for extended periods of time during the manufacture process. The transdermal matrices prepared by these methods perform better in transdermal devices and show greater flux of active agent. As a result of the improved performance, less active agent may be utilized during the manufacturing process, and smaller or thinner transdermal matrices may be produced for incorporation into the corresponding transdermal device.</p> |
