DISSOLUTION TEST SAMPLE HOLDER

摘要

A dissolution test sample holder (10) for testing topical formulations for dermal and/or transdermal drug delivery is disclosed. The holder (10) has a cylindrical tubular body (12) with an end cap (22) removably attached to one end (14). The end cap (22) has a peripheral wall (20) which frictionally engages the body (12) to hold the end cap (22) in place. A flange (24) extends perpendicularly from the peripheral wall (20) inwardly defining an aperture (26) in the end cap (22) and providing a support surface (28) for a membrane (30) held within the end cap (22). A ring (18) is positioned within the end cap (22) on the membrane (30), the membrane (30) being sandwiched between the ring (18) and the support surface (28). The ring (18) protects the membrane (30) by preventing contact between it and the body (12), and provides a volume for holding the test sample in contact with the membrane (30).