| 摘要 |
Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of general formula (I): A-N(Z)-CH(R1)C(O)-Q wherein A is represented by the formula: XO-[C(R2)<2>]<n> - wherein n is an integer of from 1 to about 3, X is selected from the group consisting of a hydrogen atom, an acyl group and a halogenated acyl group and each R<2> is independently selected from the group consisting of a hydrogen atom, an alkyl group having from 1 to about 3 carbon atoms, a hydroxyalkyl group having from 1 to about 3 carbon atoms, and CH2OX; Z is selected from the group consisting of a hydrogen atom, an alkyl group of from 1 to about 3 carbon atoms, and A; R<1> is an amino acid side chain group or an amino acid side chain group which forms with R<2> a single heterocyclic structure having a total of from 5 to 7 atoms in the ring; and wherein Q is a substituent selected from the group consisting of a hydroxyl, -N(R<2>)2, -NR<2>(NR<2>)2, -SR<2>, an alkoxy, a halogenated alkoxy, an O-acyl and an O-halogenated acyl are disclosed. Methods of treating, delaying the onset of and/or preventing antioxidant responsive diseases comprising administering such pharmaceutical antioxidant compositions and amino acid-based compounds of general formula (I) are also disclosed.
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