New human papilloma virus (HPV) vaccine formulations exhibit enhanced long-term stability. Formulation components can include: virus-like particles (VLPs) absorbed onto aluminum, a salt, non-ionic surfactant, and a buffer. Additional formulations also contain a polymeric polyanionic stabilizer and a salt either in the presence or absence buffering agents and nonionic detergent.
申请公布号
WO0045841(A2)
申请公布日期
2000.08.10
申请号
WO2000US02463
申请日期
2000.02.01
申请人
MERCK & CO., INC.;VOLKIN, DAVID, B.;SHI, LI;MACH, HENRYK