COMBINED VACCINE FOR IMMUNOPROPHYLAXIS AGAINST VIRAL HEPATITIS B AND D, TETANUS AND DIPHTHERIA

摘要

The present invention pertains to the field of medicine, more precisely to that of clinical immunology, and essentially relates to the production as well as to the use of a new complex preparation for immunoprophylaxis against various types of infections simultaneously. This invention essentially relates to the use of preparations for immunoprophylaxis against viral hepatitis B and D, tetanus and diphtheria. This invention also relates to a combined vaccine for immunoprophylaxis against viral hepatitis B ad D, tetanus and diphtheria, wherein said vaccine contains the antigens thereof as well as a builder. This vaccine is characterised in that it also contains the following members as antigens for an amount of 1 ml: an antigen of the hepatitis B virus (HBsAg) obtained by cultivating transformed cells from the strain S. cerevisiae VKPM Y-2203 in an amount of 5 to 10 mu g; a purified and concentrated diphtheric anatoxin in an amount of 5 to 30 Lf; a purified and concentrated tetanic anatoxin in an amount of 5 to 10 EC; merthiolate in an amount of 0.01 < 0.002 %; a hydroxide aluminium gel in an amount of 0.6 to 1.2 mg as converted into aluminium; and up to 1.0 ml of a pharmaceutically acceptable solvent. These preparations have a high seroconversion rate due to the mutual promoting action of the components used therein.