发明名称 |
ALLERGENIC PROTEIN AND PEPTIDES FROM HOUSE DUST MITE AND USES THEREFOR |
摘要 |
<p>Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens. <IMAGE> <IMAGE></p> |
申请公布号 |
EP0690914(B1) |
申请公布日期 |
2000.08.09 |
申请号 |
EP19940910283 |
申请日期 |
1994.03.11 |
申请人 |
INSTITUTE FOR CHILD HEALTH RESEARCH |
发明人 |
THOMAS, WAYNE ROBERT;CHUA, KAW-YAN |
分类号 |
C12N15/09;A61K38/00;A61K38/11;A61K39/00;A61K39/35;A61K39/395;A61P37/08;C07H21/04;C07K14/435;C07K14/47;C07K14/725;C12N1/15;C12N1/19;C12N1/21;C12N5/06;C12N5/10;C12N15/12;C12P21/02;C12P21/06;C12P21/08;C12Q1/02;G01N33/53;G01N33/569;G01N33/68;(IPC1-7):C12N15/12;C07K14/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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