发明名称 |
In situ activation of microcapsules |
摘要 |
Disclosed are microcapsules comprising a polymer shell enclosing two or more immiscible liquid phases in which a drug, or a prodrug and a drug activator are partitioned into separate phases, or prevented from diffusing out of the microcapsule by a liquid phase in which the drug is poorly soluble. Also disclosed are methods of using the microcapsules for in situ activation of drugs, where upon exposure to an appropriate energy source the internal phases mix and the drug is activated in situ.
|
申请公布号 |
US6099864(A) |
申请公布日期 |
2000.08.08 |
申请号 |
US19980079741 |
申请日期 |
1998.05.15 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION |
发明人 |
MORRISON, DENNIS R.;MOSIER, BENJAMIN |
分类号 |
A61K9/127;A61K9/50;A61K9/52;A61K41/00;B01J13/06;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|