发明名称 Tetracyclic spiro compounds as 5HT1B receptor antagonists
摘要 PCT No. PCT/EP97/01404 Sec. 371 Date Sep. 18, 1998 Sec. 102(e) Date Sep. 18, 1998 PCT Filed Mar. 19, 1997 PCT Pub. No. WO97/34901 PCT Pub. Date Sep. 25, 1997Compounds of formula(I) where B is oxygen or sulphur, D is nitrogen, R6 and R7 forms a ring, m is 2, R is a substituted latam ring of formula (i) where p is 1, P is a substituted or unsubstituted bicyclic ring containing one or two heteroatoms or P is an unsbustituted or substituted 5- to 7-memebered saturated ring containing one or two heteroatoms; X, Y, Z, E, G, R3, R4, R5, R8, R9, and R10 are as defined in the specification.
申请公布号 US6100272(A) 申请公布日期 2000.08.08
申请号 US19980142988 申请日期 1998.09.18
申请人 SMITHKLINE BEECHAM P.L.C. 发明人 GASTER, LARAMIE MARY;HAM, PETER;KING, FRANCIS DAVID;WYMAN, PAUL ADRIAN
分类号 A61K31/00;A61K31/435;A61K31/438;A61K31/445;A61K31/4465;A61K31/4523;A61K31/4545;A61K31/47;A61K31/472;A61K31/4725;A61K31/4747;A61K31/495;A61K31/4965;A61K31/497;A61P1/00;A61P5/00;A61P9/00;A61P9/08;A61P9/12;A61P15/00;A61P15/10;A61P25/16;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D471/10;C07D491/20;(IPC1-7):A61K31/44;C07D221/20 主分类号 A61K31/00
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