发明名称 |
Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes |
摘要 |
PCT No. PCT/ES97/00065 Sec. 371 Date Feb. 25, 1998 Sec. 102(e) Date Feb. 25, 1998 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97/34902 PCT Pub. Date Sep. 25, 1997Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for molecular weights over 10,000 Dalton and preferably over 2000 Dalton is described. For example cephalosporin-G of increased purity, represented by a 6-8% increase in the HPLC titre, with a reduction of 50% in absorbance, is obtained using this technique. The invention makes it possible for the purified products to be used directly in the synthesis of other antibiotic compounds without the need for intermediate isolation.
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申请公布号 |
US6100393(A) |
申请公布日期 |
2000.08.08 |
申请号 |
US19980945890 |
申请日期 |
1998.02.25 |
申请人 |
ANTIBIOTICOS, S.A. |
发明人 |
LOPEZ ORTIZ, JUAN FRANCISCO;FERRERO BARRUEGO, OSCAR;GONZALEZ DE PRADO, EMILIANO;VITALLER ALBA, ALEJANDRO;SALTO MALDONADO, FRANCISCO |
分类号 |
C07D501/10;C07D501/12;C07D501/22;C12P35/02;(IPC1-7):C07B63/00 |
主分类号 |
C07D501/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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