| 发明名称 |
Reductive alkylation of secondary amines with hydrosilane |
| 摘要 |
A novel process for the production of tertiary amines by reductive alkylation of second amine using hydrosilane and a Lewis acid is disclosed. The novel process has applications in the preparation of imidazole-containing benzodiazepines, inhibitors of farnesyl protein transferase.
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| 申请公布号 |
US6100395(A) |
申请公布日期 |
2000.08.08 |
| 申请号 |
US20000480202 |
申请日期 |
2000.01.10 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHEN, BANG-CHI;SUNDEEN, JOSEPH E.;GUO, PENG |
| 分类号 |
C07C209/28;C07D233/64;C07D243/14;(IPC1-7):C07C209/28;C07D333/64 |
主分类号 |
C07C209/28 |
| 代理机构 |
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