Process for the production of clavulanic acid and/or salts thereof by fermentation controlling soluble phosphate concentration

摘要

PCT No. PCT/ES96/00215 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Nov. 15, 1996 PCT Pub. No. WO97/19187 PCT Pub. Date May 29, 1997A batch fermentation is carried out continuously or semicontinuously using strain of Streptomyces clavuligerus for the production of clavulanic acid. The fermentation process is carried out with strict control of the soluble phosphate in the medium both at the beginning and throughout the process.