Medicinal compositions with improved oral absorption

摘要

Medicinal compositions with improved absorption via digestive mucosae wherein a drug (in particular, a basic drug) which is hardly absorbed via digestive mucosae, when orally administered, is blended with a substance having an effect of inhibiting the formation of a hardly absorbable complex formed by the drug with bile acid or an effect of dissociating the complex; and a method for improving the digestive absorption of a drug. Spray-dried medicinal compositions containing an aminoalkyl methacrylate copolymer E and being handled conveniently, which are prepared by dissolving the above polymer and a surfactant in a solvent followed by spray-drying; and a process for producing these compositions.