Piperidine, tetrahydropyridine and piperazine derivatives, their preparation anduse

摘要

A piperidine, tetrahydropyridine or piperazine derivative having formula (I), any of its enantiomers or any mixture thereof, or an acid addition salt thereof, wherein B is C1-10-alkylene, C1-10-alkenylene or C1-10-alkynylene; X is -O-, -S-, or CR4R5-; and Y is -CR6R7, -CR6R7-CR8R9, or CR6=CR7-; or X and Y together form a group -CR4=CR5, or -CR4-CR5-CR6R7-; Z is -O-, or -S-; W is N, C, or CH, and the dotted line is an optional bond; A is a bicyclic ring selected from (Ia) or (Ib) wherein E1, E2 and E3 are selected from O, S, N, NR11, C, CR12 and CHR13, and the dotted line indicates an optional bond, provided that E2 and E1 and/or E3 may not simultaneously be O, or S. The compounds of the invention are considered useful for the treatment of affective disorders, such as depression, psychosis, anxiety disorders including general anxiety disorder, panic disorder, obsessive compulsive disorder, and eating disorders.