发明名称 |
Fremgangsmåde til asymmetrisk syntese af S-acylerede derivater af 2-mercaptomethyl-3-phenylpropansyre og anvendelse deraf t |
摘要 |
PCT No. PCT/FR97/00218 Sec. 371 Date Nov. 26, 1997 Sec. 102(e) Date Nov. 26, 1997 PCT Filed Feb. 4, 1997 PCT Pub. No. WO97/29086 PCT Pub. Date Aug. 14, 1997Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in: a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride; b) preparing the monoacetates (VII R) or (VII S) respectively; c) subjecting these monoacetates to an oxidation in order to form the acids (IX S) or (IX R); d) saponifying the compounds (IX S) or (IX R) in order to form the hydroxy acids (X S) or (X R); e) thioacylating the hydroxy acids (X S) or (X R) with a mercapto acid R1SH (XI), according to a Mitsunobu-type reaction, in order to lead to the desired acids (I R) (I S) respectively and application to the synthesis of N-(mercaptoacyl)amino acid derivatives (II). |
申请公布号 |
DK0820439(T3) |
申请公布日期 |
2000.08.07 |
申请号 |
DK19970904485T |
申请日期 |
1997.02.04 |
申请人 |
SOCIETE CIVILE BIOPROJET |
发明人 |
SCHWARTZ, JEAN-CHARLES;LECOMTE, JEANNE-MARIE;DANVY, DENIS;MONTEIL, THIERRY;DUHAMEL, PIERRE;DUHAMEL, LUCETTE;NOEL-LEFEBRVRE, NADINE;GROS, CLAUDE;PLAQUEVENT, JEAN-CHRISTOPHE |
分类号 |
C12P7/62;C07B53/00;C07C29/149;C07C59/48;C07C327/32;(IPC1-7):C07C327/32 |
主分类号 |
C12P7/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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