摘要 |
PROBLEM TO BE SOLVED: To industrially advantageously produce a compound useful as an intermediate for agrochemicals and medicines while suppressing the production of byproducts by brominating a specific compound with bromine by using a specified radical initiator in a mixed solvent of water with an organic solvent. SOLUTION: A compound of formula I A is a group of formulas II to IV [R1 and R2 are each a (substituted) alkyl, an allyl, a propagyl or an aralkyl]} is brominated with bromine in a mixed solvent of water with an organic solvent (preferably a halogenated hydrocarbon such as chlorobenzene) by using a radical initiator having the temperature of 10-hr half-life not higher than the boiling point of the bromine [e.g. 2,2-azobis(4-methoxy-2,4-dimethylvaleronitrile) and 2,2-azobis(2,4-dimethylvaleronitrile)], preferably of 1-3 mol (based on the reactant) to provide the objective compound of formula V.
|