| 摘要 |
PROBLEM TO BE SOLVED: To provide a crystal polymorphism of 2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4- hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid having strongβ2-adrenergic receptor stimulation action andβ3-adrenergic receptor stimulation action and useful e.g. as a pain remission agent and a lithagogue for lithangiuria. SOLUTION: This crystal polymorphism gives a powder X-ray diffraction pattern having strong diffraction peaks at the diffraction angles (2θ±0.1) of 10.1, 10.4, 15.5, 17.0, 20.0 and 20.2 deg.. It can be produced by dissolving the compound in a mixture of water and methanol (at a volume ratio of 7:3 to 9:1), concentrating under reduced pressure, drying the precipitated crystal under reduced pressure at room temperature to 60 deg.C for several hours or longer and stirring in suspended state in methanol at room temperature to the refluxing temperature for several tens minutes to several hours.
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