发明名称 |
MEDICINAL COMPOSITIONS WITH CHOLESTEROL-LOWERING EFFECT |
摘要 |
<p>Pharmaceutical compositions having a cholesterol-lowering effect which comprises as the active ingredient a compound having a PPAR (peroxisome proliferator-activated receptor) delta activating effect or a PPAR delta - and PPAR gamma -activating effect or a pharmaceutically acceptable salt thereof; pharmaceutical compositions wherein the cholesterol-lowering effect is an LDL-cholesterol-lowering effect; and a method for identifying a compound having a cholesterol-lowering effect characterized by measuring the PPAR delta -activating effect or the PPAR delta - and PPAR gamma -activating effect thereof. Means for Solution: It is found out that a compound exerting an excellent cholesterol-lowering effect on higher animals such as humans and ape has an effect of activating PPAR delta or PPAR delta and PPAR gamma . Also, a method for identifying a compound having an excellent cholesterol-lowering effect was found, wherein the desired compound can be quickly and efficiently screened from among a number of compounds by measuring the PPAR delta -activating effect or the PPAR delta - and PPAR gamma -activating effect.</p> |
申请公布号 |
EP1023907(A1) |
申请公布日期 |
2000.08.02 |
申请号 |
EP19980933883 |
申请日期 |
1998.07.22 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
SHIMOKAWA, TERUHIKO;NISHIJIMA, SATOMI;MATSUDA, KOYO;IIZUMI, YUICHI;HASHIMOTO, SEIICHI |
分类号 |
A61K45/00;A61K31/19;A61K31/192;C07K14/705;C12Q1/02;(IPC1-7):A61K45/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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