| 摘要 |
The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and metabolic dysfunction, comprising the step of administering to a human determined to be susceptible to myocardial ischemia an effective amount of an insulin sensitizer; and (b) reducing hypertension comprising the step of administering to a hypertensive human determined to have normal insulin sensitivity, an effective amount of an insulin sensitizer. In a particular embodiment, the sensitizer comprises a thiazolidinedione compound, such as triglitazone. |
