| 摘要 |
The phenylalkan(en)oic acids of the formula: wherein A is i) ~NHCO~, ii) ~O~ iii) ~NHSO2~, iv) ~CO~ v) ~CH2~ or vi) ~CH(OH)~; W is ~i) C1-13 alkylene, ii) phenylene or iii) ; R is ~i) hydrogen, ii) C1-4 alkyl, iii)~COOH, iv) saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom or saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom substituted by an oxo group, A, taken together with W and R1, is two R2 are, same or different, i) hydrogen, ii) C1-4 alkyl or iii) 4-7 membered, saturated or unsaturated, mono-cyclic hetero ring containing two or three of nitrogen and sulfur in total, or two R2, taken together with a nitrogen to which they are attached, form saturated or unsaturated, i) 7-14 membered, bi-or tri-cyclic hetero ring containing one nitrogen as a hetero atom, or ii) 4-7 membered, mono-cyclic hetero ring containing two or three of nitrogen and oxygen in total ; Y is ethylene or vinylene; D is i) -Z-B II) or Z is C3-11 alkylene or alkenylene B is or Z, taken together with B, is C3-22 alkyl; R3 is i) hydrogen, ii) halogen, III) C1-8 alkyl, alkoxy or alkylthio, or iv) C2-8 alkenyl, alkenyloxy or alkenylthio; n is 1-3; R4 is C1-7 alkylene; R5 is i) C1-12 alkyl, ii) C2-12 alkenyl, iii) C5-7 cycloalkyl or iv) phenethyl or phenethyl wherein the ring is substituted by one C1-4 alkoxy; Two R6 are, same or different, i) C1-7 alkyl, ii) benzyl or iii) phenyl or phenyl wherein the ring is substituted by one C1-4 alkyl; and Two R7 are, same or different, C1-4 alky; with the proviso that i) ~A~W~R1 should bind to 3- or 4- carbon in benzene ring, and ii) when W is phenylene or , A should not represent ~O~, ~CO~, ~CH2~ or ~CH(OH)~; and non-toxic salts thereof, possess an antagonism on leukotriene B4, and therefore, are useful for the prevention and treatment of several diseases induced by leukotriene B4.
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