发明名称 |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
摘要 |
Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.
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申请公布号 |
US6096871(A) |
申请公布日期 |
2000.08.01 |
申请号 |
US19950422093 |
申请日期 |
1995.04.14 |
申请人 |
GENENTECH, INC. |
发明人 |
PRESTA, LEONARD G.;SNEDECOR, BRADLEY R. |
分类号 |
C12N15/09;A61K38/00;A61K38/21;A61K38/22;A61K38/27;A61K39/395;A61P37/02;C07K4/12;C07K14/48;C07K14/61;C07K16/00;C07K16/28;C12N1/21;C12N15/12;C12N15/13;C12N15/63;C12P21/02;C12P21/08;C12R1/19;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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