发明名称 |
Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
摘要 |
The invention relates to the process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid from a fermentation broth containing impure clavulanic acid comprising the steps of filtration of the fermented broth, extraction of the clavulanic acid to a water immiscible or partly water immiscible solvent at pH from 1.2 - 2, precipitation of an alkali metal salt A of clavulanic acid by addition of a solution of an alkali metal alkylalkanoate, characterized by the following steps: before the filtration the fermented broth containing clavulanic acid is diluted with water, a flocculating agent is added and the pH is adjusted to 3 - 5 for further purification the alkali metal salt A of clavulanic acid is converted to clavulanic acid by addition of an inorganic acid and is extracted into a water immiscible or partly water immiscible solvent a solution of a different alkali metal B alkyl alkanoate is added and the alkali metal salt B of clavulanic acid is precipitated. |
申请公布号 |
GR3032882(T3) |
申请公布日期 |
2000.07.31 |
申请号 |
GR20000400577T |
申请日期 |
2000.03.07 |
申请人 |
CIPAN-COMPANHIA INDUSTRIAL PRODUTORA DE ANTIBIOTICOS, S.A. |
发明人 |
CARDOSO, JAOQUIM P. |
分类号 |
C12P17/14;A61K31/424;A61P31/04;C07D503/00;C07D503/18;C12N9/99;C12P17/18;C12R1/465;(IPC1-7):C12P17/18 |
主分类号 |
C12P17/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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