| 摘要 |
Compound represented by structural formula (I) or a pharmaceutical acceptable salt thereof, wherein a is 0-3; b, d and e are 0-2; R is H, alkyl, F or -OR<6>; A is an optionally substituted oxime or hydrazone; d is not 0 and X is a bond, -C(O)-, -O-, -NR<9>-, -S(O)e-, -N(R<6>)C(O)-, -C(O)N(R<6>)-, -OC(O)NR<6>-, -OC(=S)NR<6>-, -N(R<6>)C(=S)O-, -S(O)2N(R<6>)-, -N(R<6>)S(O)2-, -N(R<6>)C(O)O-, -OC(O)- or -N(R<6>)C(O)NR<7>-; or d is 0 and X is a bond or -NR<6>-; T is H, aryl, heterocycloalkyl or heteroaryl; Q is phenyl, napthyl or heteroaryl; R<6> is H, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, and benzyl; R<9> is R<6> or -OR<6>, R<6a>, R<7a>, R<8a> and R<9a> are H or alkyl; Z is a nitrogen-containing heterocyclo group, e.g., piperidinyl, substituted by a heterocyclo- or heterocycloalkyl group; wherein phenyl, benzyl, aryl, heterocycloalkyl, heteroaryl and cycloalkyl groups are optionally substituted; methods of treating diseases such as asthma, cough, bronchospasm, depression, emesis, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed. |
