Homopiperazine derivatives as selective emopamil inhibitors

摘要

Homopiperazines of formula (I), wherein R<1> is hydrogen, C1-8alkyl, C2-8alkenyl or C2-8alkynyl substituted or unsubstituted with a variety of groups as defined herein; A is a ring selected from phenyl and naphthyl; R<2> at each occurrence is independently selected from a variety of groups as defined herein; m is an integer selected from the range 0 to 5 where at each occurrence R<2> is independently selected; together with processes for their manufacture and compositions containing them. Compounds of formula (I) are pharmacologically useful in the treatment of neurological disorders.