| 摘要 |
This invention relates to compositions comprising dual haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such double haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma and ovarian adenocarcinoma cells are dual-haptenized with a dinitrophenyl group coupled to epsilon -amino groups, and with a sulfanilic acid group coupled to aromatic side chains of histidine and tyrosine. The dual-haptenized tumor cells can be used in vaccine preparations at a lower dosage, and are more effective for eliciting favorable immune responses. |
